SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity
نویسندگان
چکیده
منابع مشابه
Two New p73 Splice Variants, γ and δ, with Different Transcriptional Activity
p73 has been recently identified as a new structural and functional homologue of the transcription factor p53. It is expressed in either a full-length form, alpha, or a shorter beta mRNA variant, with exon 13 spliced out. Here we report the identification and functional characterization of two new p73 splicing variants, gamma (splicing out exon 11) and delta (splicing out exons 11, 12, and 13)....
متن کاملStructure of p73 DNA-binding domain tetramer modulates p73 transactivation.
The transcription factor p73 triggers developmental pathways and overlaps stress-induced p53 transcriptional pathways. How p53-family response elements determine and regulate transcriptional specificity remains an unsolved problem. In this work, we have determined the first crystal structures of p73 DNA-binding domain tetramer bound to response elements with spacers of different length. The str...
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Identification of unique features of cancer cells is important for defining specific and efficient therapeutic targets. Mutant p53 is present in nearly half of all cancer cases, forming a promising target for pharmacological reactivation. In addition to being defective for the tumor-suppressor function, mutant p53 contributes to malignancy by blocking a p53 family member p73. Here, we describe ...
متن کاملSignaling and Regulation Pirh2, a Ubiquitin E3 Ligase, Inhibits p73 Transcriptional Activity by Promoting Its Ubiquitination
p73, a homolog of the tumor suppressor p53, transactivates many p53 target genes, leading to apoptosis or cellcycle arrest. p73 has recently been reported to play an important role in tumor suppression in amousemodel. Here, we show that Pirh2 physically interacted with p73 and downregulated p73 function through its E3 ligase activity. Pirh2 promoted p73 ubiquitination in vivo and in vitro. Intr...
متن کاملp73 in colorectal cancer
Colorectal cancer (CRC) is the third most common cancer in the world, with about 5000 new cases in Sweden every year. CRC is caused by mutation (inherited or acquired) in genes, by gene variants and changed expression of proteins. The primary way to achieve a curative result for CRC is to remove the tumor by surgery. To reduce risk of recurrence chemoor radiotherapy are given as a complement to...
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ژورنال
عنوان ژورنال: Journal of Cellular Physiology
سال: 2006
ISSN: 0021-9541,1097-4652
DOI: 10.1002/jcp.20831